Isocratic High-Performance Liquid Chromatographic Method with Ultraviolet Detection for Simultaneous Determination of Levels of Voriconazole and Itraconazole and Its Hydroxy Metabolite in Human Serum
Open Access
- 1 August 2005
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 49 (8), 3569-3571
- https://doi.org/10.1128/aac.49.8.3569-3571.2005
Abstract
A simple, specific method is presented for simultaneous determination of voriconazole and itraconazole and its metabolite, hydroxyitraconazole, in human serum using one-step liquid-liquid extraction and high-performance liquid chromatography. Linearity tests ranged from 0.1 to 8.0 μg/ml; the minimum detectable concentration was 0.03 μg/ml.Keywords
This publication has 20 references indexed in Scilit:
- Simultaneous determination of itraconazole and hydroxyitraconazole in human plasma by high-performance liquid chromatographyJournal of Chromatography A, 2004
- Liquid chromatographic method for the determination of plasma itraconazole and its hydroxy metabolite in pharmacokinetic/bioavailability studiesJournal of Chromatography B, 2003
- ItraconazoleDrugs, 1996
- Potential use of a simplified method for determination of itraconazole levels in plasma and esophageal tissue by using high-performance liquid chromatographyAntimicrobial Agents and Chemotherapy, 1995
- Syncope and cardiac arrhythmia due to an interaction between intraconazole and terfenadineAmerican Journal Of Medicine, 1993
- Discrepancies in bioassay and chromatography determinations explained by metabolism of itraconazole to hydroxyitraconazole: studies of interpatient variations in concentrationsAntimicrobial Agents and Chemotherapy, 1993
- High-dose itraconazole in the treatment of severe mycosesAntimicrobial Agents and Chemotherapy, 1991
- The Clinical Pharmacokinetics of Itraconazole: An OverviewMycoses, 1989
- Treatment of invasive aspergillosis with itraconazoleAmerican Journal Of Medicine, 1989
- Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbitsAntimicrobial Agents and Chemotherapy, 1986