Safety of Mesenchymal Stem Cells for Clinical Application
Open Access
- 1 January 2012
- journal article
- review article
- Published by Hindawi Limited in Stem Cells International
- Vol. 2012, 1-4
- https://doi.org/10.1155/2012/652034
Abstract
Mesenchymal stem cells (MSCs) hold great promise as therapeutic agents in regenerative medicine and autoimmune diseases, based on their differentiation abilities and immunosuppressive properties. However, the therapeutic applications raise a series of questions about the safety of culture-expanded MSCs for human use. This paper summarized recent findings about safety issues of MSCs, in particular their genetic stability in long-termin vitroexpansion, their cryopreservation, banking, and the role of serum in the preparation of MSCs.Funding Information
- National High Technology Research and Development Program of China (2011AA020118, 2011 CB964800, 2011CB964802)
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