INVITED REVIEW POLYMERIC DELIVERY SYSTEMS FOR CONTROLLED DRUG RELEASE
- 1 January 1980
- journal article
- research article
- Published by Informa UK Limited in Chemical Engineering Communications
- Vol. 6 (1-3), 1-48
- https://doi.org/10.1080/00986448008912519
Abstract
The use of polymers to provide controlled long-term delivery of drugs and other chemicals is a rapidly emerging field. This review focuses primarily on the applications of these polymeric systems, and their release mechanisms. Examples of applications include clinical, pharmaceutical, biological, agricultural, environmental, and household uses. Release mechanisms considered are diffusive (reservoirs, matrices), chemical (biocrosion, pendent chain), swelling, and magnetic control of drug release from polymers. Advantages and disadvantages of controlled-release technology, and approaches for developing and testing effective polymeric delivery systems arediscussed.Keywords
This publication has 89 references indexed in Scilit:
- A simple method for studying chemotaxis using sustained release of attractants from inert polymersCanadian Journal of Microbiology, 1980
- Controlled Release of Tetracycline II: Development of an In Vivo Flow-Limited Pharmacokinetic ModelJournal of Pharmaceutical Sciences, 1979
- Progestin Permeation Through Polymer Membranes III: Polymerization Solvent Effect on Progesterone Permeation Through Hydrogel MembranesJournal of Pharmaceutical Sciences, 1979
- Reduction to Normal of Plasma Glucose in Juvenile Diabetes by Subcutaneous Administration of Insulin with a Portable Infusion PumpNew England Journal of Medicine, 1979
- Development of an Estriol-Releasing Intrauterine DeviceJournal of Pharmaceutical Sciences, 1979
- Antibiotics in acrylic bone cement.In vivo studiesJournal of Biomedical Materials Research, 1978
- Chronic dependence with a sustained ethanol release implant in miceLife Sciences, 1978
- A MINIATURE SYRINGE PUMP FOR CONTINUOUS ADMINISTRATION OF DRUGS AND HORMONES: THE MILL HILL INFUSERThe Lancet, 1977
- Lactic/glycolic acid polymers as narcotic antagonist delivery systemsLife Sciences, 1975
- Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matricesJournal of Pharmaceutical Sciences, 1963