Fast mapping of myocardial blood flow with MR first‐pass perfusion imaging
Open Access
- 17 April 2008
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 59 (6), 1394-1400
- https://doi.org/10.1002/mrm.21559
Abstract
Accurate and fast quantification of myocardial blood flow (MBF) with MR first-pass perfusion imaging techniques on a pixel-by-pixel basis remains difficult due to relatively long calculation times and noise-sensitive algorithms. In this study, Zierler's central volume principle was used to develop an algorithm for the calculation of MBF with few assumptions on the shapes of residue curves. Simulation was performed to evaluate the accuracy of this algorithm in the determination of MBF. To examine our algorithm in vivo, studies were performed in nine normal dogs. Two first-pass perfusion imaging sessions were performed with the administration of the intravascular contrast agent Gadomer at rest and during dipyridamole-induced vasodilation. Radiolabeled microspheres were injected to measure MBF at the same time. MBF measurements in dogs using MR methods correlated well with the microsphere measurements (R2 = 0.96, slope = 0.9), demonstrating a fair accuracy in the perfusion measurements at rest and during the vasodilation stress. In addition to its accuracy, this method can also be optimized to run relatively fast, providing potential for fast and accurate myocardial perfusion mapping in a clinical setting. Magn Reson Med, 2008.Keywords
This publication has 21 references indexed in Scilit:
- Microvascular perfusion 1 week and 6 months after myocardial infarction by first-pass perfusion cardiovascular magnetic resonance imagingHeart, 2006
- Improvement of quantification of myocardial first‐pass perfusion mapping: A temporal and spatial wavelet denoising methodMagnetic Resonance in Medicine, 2006
- Magnetic resonance first pass perfusion imaging for detecting coronary artery diseaseEuropean Journal of Radiology, 2006
- Quantitative myocardial perfusion analysis with a dual‐bolus contrast‐enhanced first‐pass MRI technique in humansJournal of Magnetic Resonance Imaging, 2006
- Resting Myocardial Blood Flow Is Impaired in Hibernating MyocardiumCirculation, 2005
- Evaluation of heart perfusion in patients with acute myocardial infarction using dynamic contrast‐enhanced magnetic resonance imagingJournal of Magnetic Resonance Imaging, 2004
- Time Delay for Arrival of MR Contrast Agent in Collateral-Dependent MyocardiumIEEE Transactions on Medical Imaging, 2004
- Analysis of myocardial perfusion MRIJournal of Magnetic Resonance Imaging, 2004
- Mapping myocardial perfusion with an intravascular MR contrast agent: Robustness of deconvolution methods at various blood flowsMagnetic Resonance in Medicine, 2002
- Blood flow measurements with radionuclide-labeled particlesProgress in Cardiovascular Diseases, 1977