TOPK promotes lung cancer resistance to EGFR tyrosine kinase inhibitors by phosphorylating and activating c-Jun

Abstract

// <![CDATA[ $('.header-date').hide();$('#titleAuthors').hide();$('#abstractHeader').hide(); // ]]> Ying Li1,*, Zhiwei Yang2,5,*, Weijie Li1,*, Shudi Xu1,6,*, Tao Wang4, Ting Wang3, Mengjie Niu1, Shengli Zhang2, Lintao Jia3 and Shengqing Li1 1 Department of Pulmonary and Critical Care Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, China 2 Department of Applied Physics, School of Science, Xi’an Jiaotong University, Xi’an, China 3 State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi‘an, China 4 Department of Neurology, Shaanxi Provincial People’s Hospital, Xi’an, China 5 Engineering Research Center of Forest Bio-preparation, Ministry of Education, Northeast Forestry University, Harbin, China 6 Department of Pulmonary Medicine, Xi’an Ninth Hospital, Xi’an, China * These authors have contributed equally to this work Correspondence to: Shengqing Li, email: // <![CDATA[ mail("shengqingli","hotmail",0,"") // ]]> Lintao Jia, email: // <![CDATA[ mail("jialth","fmmu.edu",23,"") // ]]> Keywords: TOPK, lung cancer, EGFR-TKI resistance, c-Jun, AP-1 Received: June 21, 2015 Accepted: December 31, 2015 Published: January 06, 2016