Association of Narrow Angles With Anterior Chamber Area and Volume Measured With Anterior-Segment Optical Coherence Tomography

Abstract

Primary angle-closure glaucoma (PACG) is a major cause of visual morbidity, especially in East Asia.^1-4 Detection of risk factors and early markers for PACG is necessary for formulating strategies for screening, prevention, and treatment of this disease. Several studies have previously reported ocular biometric risk factors for PACG, such as a shallow anterior chamber depth (ACD), thick and anteriorly placed lens, and short axial length (AL).^5-8 We recently conducted a study in Singapore that demonstrated that the strongest predictors for angle closure were female sex, shorter AL, shallower ACD, and Chinese race/ethnicity.⁶ However, sex and racial differences for risk of angle closure were not fully explained by variations in AL or ACD alone,⁶ suggesting that risk factors other than those observed may be important.