Selective Serotonin Reuptake Inhibitor‐Induced Rash: Case Report and Review of the Literature
- 1 April 2002
- journal article
- case report
- Published by Wiley in Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
- Vol. 22 (4), 516-518
- https://doi.org/10.1592/phco.22.7.516.33666
Abstract
Selective serotonin reuptake inhibitors (SSRIs) are one of the most frequently prescribed classes of drugs. Rashes induced by SSRIs seldom have been reported in the literature. Computerized MEDLINE and Current Contents searches yielded a report of two cases of rash induced specifically by paroxetine. We describe a patient who developed a rash that appeared on day 3 of treatment with oral paroxetine 20 mg/day. Her rash was morbilliform, pruritic, and generalized over the trunk and limbs, with some facial involvement. There was no palm or sole involvement. The patient reported that she had experienced a similar reaction to fluoxetine, which may suggest a drug class effect. The rash resolved within 2 days of drug discontinuation and treatment with oral diphenhydramine and topical hydrocortisone cream.Keywords
This publication has 6 references indexed in Scilit:
- Critical OverviewPublished by Physicians Postgraduate Press, Inc ,1999
- Adverse Reactions of Selective Serotonin Reuptake InhibitorsDrug Safety, 1999
- Systematic Review and Guide to Selection of Selective Serotonin Reuptake InhibitorsDrugs, 1999
- Adverse Cutaneous Reactions to Psychotropic DrugsPsychosomatics, 1997
- Tolerance and side-effects of paroxetine in elderly depressed patientsArchives of Gerontology and Geriatrics, 1997
- Adverse cutaneous reactions to antidepressantsAmerican Journal of Psychiatry, 1988