Cytokine release in sepsis
Open Access
- 1 January 2013
- journal article
- Published by Scientific Research Publishing, Inc. in Advances in Bioscience and Biotechnology
- Vol. 04 (09), 860-865
- https://doi.org/10.4236/abb.2013.49114
Abstract
Despite the advances in the therapeutic approaches, health care protocols and policies, sepsis continues to be an important problem in clinical medicine. High lethality of sepsis cases calls for a detailed and critically important study of the pathophysiology of sepsis. In this review, we discuss pathomechanisms of sepsis and the role of cytokines that are released in sepsis. We propose that the systemic levels of cytokines are not always reflecting the pathological picture and the immune status of the patient. One of the emerging approaches which may bring an effective treatment strategy exploits the endocannabinoid system for its immunomodulatory properties. Following from that, the research in this particular field is very important as it can bring understanding behind the complicated pathophysiology of sepsis. </pKeywords
This publication has 22 references indexed in Scilit:
- Inhibition of endocannabinoid degradation in experimental endotoxemia reduces leukocyte adhesion and improves capillary perfusion in the gutJournal of Basic and Clinical Physiology and Pharmacology, 2013
- Anti-Inflammatory Mechanisms of SepsisPublished by S. Karger AG ,2011
- Steroid therapy of septic shock: The decision is in the eye of the beholderCritical Care Medicine, 2008
- Contribution of anti-inflammatory/immune suppressive processes to the pathology of sepsisFrontiers in Bioscience-Landmark, 2006
- Proinflammatory CytokinesChest, 2000
- Anti-Inflammatory CytokinesChest, 2000
- SEVERE SEPSIS AND SEPTIC SHOCKCritical Care Clinics, 2000
- What is the role of interleukin 10 in polymicrobial sepsis: Anti-inflammatory agent or immunosuppressant?Surgery, 1999
- Treating Patients with Severe SepsisNew England Journal of Medicine, 1999
- Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in SepsisChest, 1992