Estimating the Influenza Vaccine Effectiveness against Medically Attended Influenza in Clinical Settings: A Hospital-Based Case-Control Study with a Rapid Diagnostic Test in Japan
Open Access
- 11 January 2013
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 8 (1), e52103
- https://doi.org/10.1371/journal.pone.0052103
Abstract
Influenza vaccine effectiveness (VE) studies are usually conducted by specialized agencies and require time and resources. The objective of this study was to estimate the influenza VE against medically attended influenza using a test-negative case-control design with rapid influenza diagnostic tests (RIDT) in a clinical setting. A prospective study was conducted at a community hospital in Nagasaki, western Japan during the 2010/11 influenza season. All outpatients aged 15 years and older with influenza-like illnesses (ILI) who had undergone RIDT were enrolled. A test-negative case-control design was applied to estimate the VEs: the cases were ILI patients with positive RIDT results and the controls were ILI patients with negative RIDT results. Information on patient characteristics, including vaccination histories, was collected using questionnaires and medical records. Between December 2010 and April 2011, 526 ILI patients were tested with RIDT, and 476 were eligible for the analysis. The overall VE estimate against medically attended influenza was 47.6%, after adjusting for the patients' age groups, presence of chronic conditions, month of visit, and smoking and alcohol use. The seasonal influenza vaccine reduced the risk of medically attended influenza by 60.9% for patients less than 50 years of age, but a significant reduction was not observed for patients 50 years of age and older. A sensitivity analysis provided similar figures. The test-negative case-control study using RIDT provided moderate influenza VE consistent with other reports. Utilizing the commonly used RIDT to estimate VE provides rapid assessment of VE; however, it may require validation with more specific endpoint.This publication has 32 references indexed in Scilit:
- Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysisThe Lancet Infectious Diseases, 2012
- Performance of rapid influenza H1N1 diagnostic tests: a meta‐analysisInfluenza and Other Respiratory Viruses, 2011
- Effectiveness of Non-Adjuvanted Pandemic Influenza A Vaccines for Preventing Pandemic Influenza Acute Respiratory Illness Visits in 4 U.S. CommunitiesPLOS ONE, 2011
- Effectiveness of a MF-59™-adjuvanted pandemic influenza vaccine to prevent 2009 A/H1N1 influenza-related hospitalisation; a matched case-control studyBMC Infectious Diseases, 2011
- Efficacy Studies of Influenza Vaccines: Effect of End Points Used and Characteristics of Vaccine FailuresThe Journal of Infectious Diseases, 2011
- Estimates of Pandemic Influenza Vaccine Effectiveness in Europe, 2009–2010: Results of Influenza Monitoring Vaccine Effectiveness in Europe (I-MOVE) Multicentre Case-Control StudyPLoS Medicine, 2011
- The relative efficacy of trivalent live attenuated and inactivated influenza vaccines in children and adultsInfluenza and Other Respiratory Viruses, 2010
- Study designs for timely estimation of influenza vaccine effectiveness using European sentinel practitioner networksVaccine, 2010
- Clinical Aspects of Pandemic 2009 Influenza A (H1N1) Virus InfectionThe New England Journal of Medicine, 2010
- Effectiveness of Inactivated Influenza Vaccines Varied Substantially with Antigenic Match from the 2004–2005 Season to the 2006–2007 SeasonThe Journal of Infectious Diseases, 2009