Expression of the microRNA regulators Drosha, Dicer and Ago2 in non-small cell lung carcinomas
- 31 July 2015
- journal article
- research article
- Published by Springer Science and Business Media LLC in Cellular Oncology
- Vol. 38 (4), 307-317
- https://doi.org/10.1007/s13402-015-0231-y
Abstract
MicroRNAs are evolutionarily conserved non-coding components of the transcriptome that can post-transcriptionally control gene expression. Altered microRNA expression has been found to be a common feature of several cancers, including lung carcinomas. The biogenesis and maturation of microRNAs is known to be mediated by the ribonucleases Drosha, Dicer and Ago2. The purpose of the present study was to investigate the expression and distribution of Drosha, Dicer and Ago2 in human non-small cell lung carcinomas (NSCLC) and to relate the respective expression patterns to clinocopatholical features.Keywords
This publication has 50 references indexed in Scilit:
- miRNAs in human cancerThe Journal of Pathology, 2010
- Mammalian microRNAs predominantly act to decrease target mRNA levelsNature, 2010
- Phosphorylation of the RNase III enzyme Drosha at Serine300 or Serine302 is required for its nuclear localizationNucleic Acids Research, 2010
- MicroRNA Expression and Virulence in Pandemic Influenza Virus-Infected MiceJournal of Virology, 2010
- Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotypeBritish Journal of Cancer, 2009
- Dicer, Drosha, and Outcomes in Patients with Ovarian CancerThe New England Journal of Medicine, 2008
- Most mammalian mRNAs are conserved targets of microRNAsGenome Research, 2008
- Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cellsDevelopmental Biology, 2007
- Maternally imprinted microRNAs are differentially expressed during mouse and human lung developmentDevelopmental Dynamics, 2006
- Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA TargetsCell, 2005