Master Stem Cell Transcription Factors and Signaling Regulation
- 1 February 2010
- journal article
- review article
- Published by Mary Ann Liebert Inc in Cellular Reprogramming
- Vol. 12 (1), 3-13
- https://doi.org/10.1089/cell.2009.0033
Abstract
The present article reviews master stem cell transcription factors, their expression regulation network, and related signaling pathways with the aim of understanding the molecular mechanisms of pluripotent cell fate decisions. Oct4, Sox2, and Nanog are master transcription factors for maintenance of the undifferentiated state and self-renewal of embryonic stem cells (ESCs). In the mouse, they form a regulatory circuitry with coregulators, such as beta-catenin, Stat3, Myc, Klfs, Sall4, and Esrrb to control the expression of pluripotency-related genes including themselves. The threshold expression of Oct4, Sox2, and Nanog for sustaining ESC properties depends on the synergistic effects among Stat3, beta-catenin, and Smad signaling pathway under the specific conditions of the ESC cytoplasmic microenvironment. Some of the salient differences in human ESC signaling pathways affecting their fate commitment are highlighted.Keywords
This publication has 120 references indexed in Scilit:
- A Complex Role for FGF-2 in Self-Renewal, Survival, and Adhesion of Human Embryonic Stem CellsThe International Journal of Cell Cloning, 2009
- Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming FactorsCell, 2009
- NANOG Is a Direct Target of TGFβ/Activin-Mediated SMAD Signaling in Human ESCsCell Stem Cell, 2008
- The ground state of embryonic stem cell self-renewalNature, 2008
- Generation of germline-competent induced pluripotent stem cellsNature, 2007
- Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined FactorsCell, 2006
- Dissecting self-renewal in stem cells with RNA interferenceNature, 2006
- The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cellsNature Genetics, 2006
- Core Transcriptional Regulatory Circuitry in Human Embryonic Stem CellsCell, 2005
- Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cellsNature, 1988