Impact of depression on quality of life in people living with human T cell lymphotropic virus type 1 (HTLV-1) in Salvador, Brazil
- 23 November 2011
- journal article
- Published by Springer Science and Business Media LLC in Quality of Life Research
- Vol. 21 (9), 1545-1550
- https://doi.org/10.1007/s11136-011-0066-6
Abstract
A previous study found the prevalence of depression in HTLV-1-infected patients to be approximately 30%, but few studies have attempted to correlate depression with quality of life (QOL) in these patients. The present study investigates the association between depression and QOL in people living with HTLV-1. A clinical-epidemiological questionnaire, the Mini International Neuropsychiatric Interview and the WHOQOL-Bref were applied to 88 HTLV-1-infected patients (32 with TSP/HAM) at the HTLV Center of the Bahiana School of Medicine and Public Health, Salvador, Brazil. The prevalence of depression among people living with HTLV-1 was 34.1%. Depression was significantly associated with a poor QOL in the physical, psychological, social relationship and environment domains, when controlling for other variables, such as gender, age, time of knowledge of serological diagnosis and presence of tropical spastic paraparesis/HTLV-1associated myelopathy (TSP/HAM). Moreover, patients with TSP/HAM experienced a reduction in their QOL in the physical, psychological and environment domains. Our results showed that depression negatively affects the quality of life of people living with HTLV-1, regardless of the presence of TSP/HAM. Since it is possible to improve a patient's QOL by treating depression, psychological evaluations are strongly recommended as a measure to integrate the treatment protocols of HTLV-1 intervention programs.Keywords
This publication has 36 references indexed in Scilit:
- Functional Biomarkers of Depression: Diagnosis, Treatment, and PathophysiologyNeuropsychopharmacology, 2011
- Characteristics of Chronic Pain and Its Impact on Quality of Life of Patients With HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)The Clinical Journal of Pain, 2011
- A Meta-Analysis of Cytokines in Major DepressionBiological Psychiatry, 2010
- Higher Rate of Major Depression among Blood Donor Candidates Infected with Human T-Cell Lymphotropic Virus Type 1The International Journal of Psychiatry in Medicine, 2008
- Proposal for Diagnostic Criteria of Tropical Spastic Paraparesis/HTLV-I-Associated Myelopathy (TSP/HAM)AIDS Research and Human Retroviruses, 2006
- Human T Cell Lymphotropic Viruses (HTLV-I/II) in South America: Should It Be a Public Health Concern?Journal of Biomedical Science, 2002
- Mini International Neuropsychiatric Interview (MINI): validação de entrevista breve para diagnóstico de transtornos mentaisRevista Brasileira de Psiquiatria, 2000
- ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESISThe Lancet, 1985
- Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.Proceedings of the National Academy of Sciences of the United States of America, 1982
- Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphomaProceedings of the National Academy of Sciences of the United States of America, 1980