Age at menarche and adult BMI in the Aberdeen Children of the 1950s Cohort Study
Open Access
- 1 October 2005
- journal article
- research article
- Published by Elsevier BV in The American Journal of Clinical Nutrition
- Vol. 82 (4), 733-739
- https://doi.org/10.1093/ajcn/82.4.733
Abstract
Background:Few studies have examined whether the inverse association of age at menarche with adult body mass index (BMI) is due to the tendency of BMI to track between childhood and adult life, with childhood BMI playing a causal role in determining age at menarche. Objective:The objective was to investigate whether the association of younger age at menarche with a high BMI and increased likelihood of obesity in middle age is due to confounding with early childhood BMI. Design:In a historical cohort of 3743 Scottish females born between 1950 and 1955, height and weight were measured in early childhood, and age at menarche and height and weight in middle age were obtained by questionnaire. Results:The age-adjusted change in mean adult BMI per additional year of age at menarche was −0.64 (95% CI: −0.78, −0.50). Adjustment for childhood BMI measured between 4 and 6 y reduced this value to −0.57 (−0.71, −0.43). Adjustment for childhood and adult social class, parity, smoking, and alcohol intake had little effect. The odds ratio for being obese compared with not being obese in adulthood was 0.82 (0.76, 0.86) per 1-y increase in age at menarche and was unchanged by adjustment for childhood BMI and other covariates. Conclusions:The inverse association of age at menarche with BMI and obesity in middle age is not explained by confounding by early childhood BMI. Instead, age at menarche may simply be a proxy marker for the pace of sexual maturation, which itself leads to differences in adiposity (and BMI) in the peripubertal period that track into adult life.Keywords
This publication has 35 references indexed in Scilit:
- Precocious pubarche is associated with SGA, prematurity, weight gain, and obesityArchives of Disease in Childhood, 2005
- Puberty, obesity and ethnicityTrends in Endocrinology & Metabolism, 2004
- The AberdeenChildren of the 1950scohort study: background, methods and follow‐up information on a new resource for the study of life course and intergenerational influences on healthPaediatric and Perinatal Epidemiology, 2004
- Validity of self-reported height and weight in 4808 EPIC–Oxford participantsPublic Health Nutrition, 2002
- Recall of Early Menstrual History and Menarcheal Body Size: After 30 Years, How Well Do Women Remember?American Journal of Epidemiology, 2002
- Age at menarche: secular trends and association with adult anthropometric measuresAnnals of Human Biology, 2001
- Accuracy of the estimated prevalence of obesity from self reported height and weight in an adult Scottish populationJournal of Epidemiology and Community Health, 2000
- Body size and the menarche: The Dunedin studyJournal of Adolescent Health, 1994
- Trend in menarcheal age and socioeconomic influence in Bologna (Northern Italy)Annals of Human Biology, 1994
- Onset of obesity in a 36 year birth cohort study.BMJ, 1986