Esophageal Dysmotility in Children With Eosinophilic Esophagitis
- 1 December 2009
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in The American Journal of Gastroenterology
- Vol. 104 (12), 3050-3057
- https://doi.org/10.1038/ajg.2009.543
Abstract
The pathophysiology of dysphagia in patients with eosinophilic esophagitis (EoE) is unknown but may be related to abnormal esophageal motor function. Symptoms rarely occur during stationary esophageal manometry, so it has been difficult to establish an association between symptoms and motor events. Our aim was to evaluate esophageal motor function in children with EoE with the use of stationary manometry and ambulatory prolonged esophageal manometry and pH-metry (PEMP). PEMP was performed in children with EoE and compared with controls and children with gastroesophageal reflux disease (GERD). Peristalsis was considered effective when the esophageal contractions had a normal amplitude and propagation. Results are expressed as mean±s.e. Seventeen patients with EoE, 13 with GERD, and 11 controls were studied. Values are expressed as mean±s.e. Stationary manometry identified abnormal peristalsis in 41% of children with EoE. During PEMP, children with EoE had an increased number of isolated (16.7±3.8 vs. 9.5±1.6 vs. 6.5±1.1; PPPP<0.05) when compared with children with GERD and controls. Thirteen patients with EoE experienced 21 episodes of dysphagia, and all correlated with simultaneous abnormal motor function. PEMP allowed the detection of ineffective peristalsis in children with EoE. Symptoms observed in children with EoE may be related to esophageal motor dysfunction.Keywords
This publication has 33 references indexed in Scilit:
- Eosinophilic oesophagitis in adultsNeurogastroenterology & Motility, 2009
- 14 Years of Eosinophilic Esophagitis: Clinical Features and PrognosisJournal of Pediatric Gastroenterology and Nutrition, 2009
- Esophageal Dysmotility in Patients Who Have Eosinophilic EsophagitisGastrointestinal Endoscopy Clinics of North America, 2008
- Eosinophilic Esophagitis in Children and Adults: A Systematic Review and Consensus Recommendations for Diagnosis and Treatment: Sponsored by the American Gastroenterological Association (AGA) Institute and North American Society of Pediatric Gastroenterology, Hepatology, and NutritionGastroenterology, 2007
- Summary of the First International Gastrointestinal Eosinophil Research SymposiumJournal of Pediatric Gastroenterology and Nutrition, 2007
- Esophageal Subepithelial Fibrosis in Children With Eosinophilic EsophagitisJournal of Pediatric Gastroenterology and Nutrition, 2007
- Endoscopic, bioptic, and manometric findings in eosinophilic esophagitis before and after steroid therapy: a case seriesEndoscopy, 2007
- Defining a Link with Asthma in Mice Congenitally Deficient in EosinophilsScience, 2004
- Association of Schatzki Ring With Eosinophilic Esophagitis in ChildrenJournal of Pediatric Gastroenterology and Nutrition, 2004
- Prolonged Monitoring of Esophageal Motor Function in Healthy ChildrenJournal of Pediatric Gastroenterology and Nutrition, 2004