The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting
Top Cited Papers
- 21 March 2013
- journal article
- research article
- Published by Annual Reviews in Annual Review of Immunology
- Vol. 31 (1), 563-604
- https://doi.org/10.1146/annurev-immunol-020711-074950
Abstract
Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune responses according to peripheral cues. After four decades of research, we now know that DCs arise from a hematopoietic lineage distinct from other leukocytes, establishing the DC system as a unique hematopoietic branch. Recent work has also established that tissue DCs consist of developmentally and functionally distinct subsets that differentially regulate T lymphocyte function. This review discusses major advances in our understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ.Keywords
This publication has 178 references indexed in Scilit:
- Densely Interconnected Transcriptional Circuits Control Cell States in Human HematopoiesisCell, 2011
- Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell AreasCell, 2010
- The Transcription Factor PU.1 Controls Dendritic Cell Development and Flt3 Cytokine Receptor Expression in a Dose-Dependent MannerImmunity, 2010
- Intracellular mechanisms of antigen cross presentation in dendritic cellsCurrent Opinion in Immunology, 2010
- Regulation of plasmacytoid dendritic cell developmentCurrent Opinion in Immunology, 2010
- Origin of the Lamina Propria Dendritic Cell NetworkImmunity, 2009
- A Role for Lipid Bodies in the Cross-presentation of Phagocytosed Antigens by MHC Class I in Dendritic CellsImmunity, 2009
- Transcription Factor E2-2 Is an Essential and Specific Regulator of Plasmacytoid Dendritic Cell DevelopmentCell, 2008
- Immunosurveillance by Hematopoietic Progenitor Cells Trafficking through Blood, Lymph, and Peripheral TissuesCell, 2007
- TLR agonists induce the differentiation of human bone marrow CD34+ progenitors into CD11c+ CD80/86+ DC capable of inducing a Th1‐type responseEuropean Journal of Immunology, 2007