The Adsorption of Vancomycin by Polyacrylonitrile, Polyamide, and Polysulfone Hemofilters
- 2 August 2007
- journal article
- Published by Wiley in Artificial Organs
- Vol. 32 (1), 81-84
- https://doi.org/10.1111/j.1525-1594.2007.00460.x
Abstract
The aim of this study was to characterize vancomycin adsorption by polyacrylonitrile (PAN), polyamide, and polysulfone hemofilters using an in vitro model of hemofiltration. Vancomycin (36 mg) was added to a blood‐crystalloid mixture of known volume (target concentration of 50 mg/L) and pumped around a closed circuit. Adsorption, which was calculated from the fall in concentration over 120 min, was significantly greater by 0.6‐m2 PAN filters (10.08 ± 2.26 mg) than by 0.6‐m2 polyamide (5.20 ± 1.82 mg) or 0.7‐m2 polysulfone (4.80 ± 2.40 mg) filters (P < 0.05). Cumulative adsorption was not changed by the addition of 500‐mL lactated Ringer's solution (to reduce the circulating vancomycin concentration). These data show that although adsorption of vancomycin by PAN, polyamide, and polysulfone hemofilters occurs, the absolute adsorption is small. Adsorption is dependent on filter material and is not reversed by a decrease in circulating concentration.Keywords
This publication has 10 references indexed in Scilit:
- Effect of drug concentration on adsorption of levofloxacin by polyacrylonitrile haemofiltersInternational Journal of Antimicrobial Agents, 2006
- Vancomycin pharmacokinetics in critically ill patients receiving continuous venovenous haemodiafiltrationBritish Journal of Clinical Pharmacology, 2004
- Higher Renal Replacement Therapy Dose Delivery Influences on Drug TherapyArtificial Organs, 2003
- Pharmacokinetics and drug dosing adjustments during continuous venovenous hemofiltration or hemodiafiltration in critically ill patientsActa Anaesthesiologica Scandinavica, 2001
- Continuous haemofiltration in the intensive care unitCritical Care, 2000
- Vancomycin clearance during continuous venovenous haemofiltration in critically ill patientsIntensive Care Medicine, 1999
- Elimination of Meropenem by Continuous Hemo(Dia) Filtration: An in Vitro One-Compartment ModelThe International Journal of Artificial Organs, 1999
- Comparison of high-performance liquid chromatography with fluorescence polarization immunoassay for the analysis of vancomycin in patients with chronic renal failureJournal of Chromatography B: Biomedical Sciences and Applications, 1995
- Acid-base properties and proton-speciation of vancomycinInternational Journal of Pharmaceutics, 1993
- Removal of vancomycin by high-flux hemodialysis membranesAntimicrobial Agents and Chemotherapy, 1992