Activation of thec-mycOncogene in a Precursor-B-Cell Blast Crisis of Follicular Lymphoma, Presenting as Composite Lymphoma
- 26 May 1988
- journal article
- case report
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 318 (21), 1373-1378
- https://doi.org/10.1056/nejm198805263182106
Abstract
B-CELL lymphomas are considered to represent "frozen" stages in the maturation of normal B cells. However, progression to a more malignant histologic form is frequently observed in low-grade lymphomas.1 Cytogenetic studies have shown that sub-clones can develop during the course of the disease, identifiable by a cascade of multiple recurrent chromosomal abnormalities.2 , 3 In follicular lymphoma, for example, these abnormalities may be superimposed on translocation t(14;18)(q32;q21), which is found as a marker in about 85 percent of cases and involves the putative oncogene bcl-2.4 Although several of these aberrations could be correlated with histologic progression, development of leukemia, or a poor . . .Keywords
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