First permanent implant of the Jarvik 2000 Heart
- 1 September 2000
- journal article
- Published by Elsevier BV in The Lancet
- Vol. 356 (9233), 900-903
- https://doi.org/10.1016/s0140-6736(00)02680-5
Abstract
Summary Background Heart failure is a major public-health concern. Quality and duration of life on maximum medical therapy are poor. The availability of donor hearts is severely limited, therefore an alternative approach is necessary. We have explored the use of a new type of left-ventricular assist device intended as a long-term solution to end-stage heart failure. Methods As part of a prospective clinical trial, we implanted the first permanent Jarvik 2000 Heart—an intraventricular device with an innovative power delivery system—into a 61-year-old man (New York Heart Association functional class IV) with dilated cardiomyopathy. We assessed the effect of this left-ventricular assist device on both native heart function and the symptoms and systemic characteristics of heart failure. Findings The Jarvik 2000 Heart sustained the patient's circulation, and was practical and user-friendly. After 6 weeks, exercise tolerance, myocardial function, and end-organ function improved. Symptoms of heart failure have resolved, and continuous decreased pulse-pressure perfusion has had no adverse effects in the short term. There has been no significant haemolysis and no device-related complications. The skull-mounted pedestal is unobtrusive and has healed well. Conclusions The initial success of this procedure raises the possibility of a new treatment for end-stage heart failure. In the longer term, its role will be determined by mechanical reliability.This publication has 12 references indexed in Scilit:
- Jarvik 2000 HeartCirculation, 1998
- Cerebral and Systemic Embolization During Left Ventricular Support With the Novacor N100 DeviceThe Annals of Thoracic Surgery, 1998
- LVAD Power Delivery: A Percutaneous Approach to Avoid InfectionThe Annals of Thoracic Surgery, 1998
- Weaning From Mechanical Cardiac Support in Patients With Idiopathic Dilated CardiomyopathyCirculation, 1997
- Improved Left Ventricular Function After Chronic Left Ventricular UnloadingThe Annals of Thoracic Surgery, 1996
- Implantable LVAD infections: Implications for permanent use of the deviceThe Annals of Thoracic Surgery, 1996
- Measurement of health-related quality of life in heart failureJournal of the American College of Cardiology, 1993
- Percutaneous Pedestal in Cochlear ImplantationAnnals of Otology, Rhinology & Laryngology, 1990
- Predicting Intellectual Level from the Mini-Mental State ExaminationJournal of the American Geriatrics Society, 1988
- Clinical Use of the Total Artificial HeartNew England Journal of Medicine, 1984