Homozygosity for human leucocyte antigen‐C ligands of KIR2DL1 is associated with increased risk of relapse after human leucocyte antigen‐C‐matched unrelated donor haematopoietic stem cell transplantation
- 31 October 2005
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 131 (4), 483-486
- https://doi.org/10.1111/j.1365-2141.2005.05797.x
Abstract
Human leucocyte antigen (HLA)-C molecules regulate the function of natural killer cells and may be subdivided into two groups, C(1) and C(2), based on their specificity for inhibitory killer immunoglobulin-like receptors. We analysed the impact of the HLA-C genotype on outcome of HLA-C-matched unrelated donor haematopoietic stem cell transplantation (URD-HSCT) recipients. HLA-C(2) homozygous patients (n = 18) had lower probability of overall survival (P = 0.01) and disease-free survival (P = 0.02), resulting from increased relapse rate (P = 0.02) when compared with both HLA-C(1) homozygous (n = 43) and HLA-C(1),C(2) heterozygous (n = 50) subgroups. Patients lacking HLA-C(1) should, therefore, be considered at increased risk of relapse following HLA-C-matched URD-HSCT.Keywords
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