Sirolimus-Eluting Stent Versus Paclitaxel-Eluting Stent for Patients With Long Coronary Artery Disease
- 14 November 2006
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 114 (20), 2148-2153
- https://doi.org/10.1161/circulationaha.106.666396
Abstract
Background— Outcomes remain relatively unfavorable for stent-based coronary intervention of lesions with long diseased segments. This study compared sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) for long coronary lesions. Methods and Results— The present randomized, multicenter, prospective study compared the use of long (≥32 mm) SES with PES in 500 patients with long (≥25 mm) native coronary lesions. The primary end point of the trial was the rate of binary in-segment restenosis according to follow-up angiography at 6 months. The SES and PES groups had similar baseline characteristics. Lesion length was 33.9±11.6 mm in the SES group and 34.5±12.6 mm in the PES group ( P =0.527). The in-segment binary restenosis rate was significantly lower in the SES group than in the PES group (3.3% versus 14.6%; relative risk 0.23; P P P =0.031). Consequently, SES patients had a lower rate of target-lesion revascularization at 9 months (2.4% versus 7.2%, P =0.012). The incidence of death (0.8% in SES versus 0% in PES, P =0.499) or myocardial infarction (8.8% in SES versus 10.8% in PES, P =0.452) at 9 months of follow-up was not statistically different between the 2 groups. Conclusions— For patients with long native coronary artery disease, SES implantation was associated with a reduced incidence of angiographic restenosis and a reduced need for target-lesion revascularization compared with PES implantation.Keywords
This publication has 24 references indexed in Scilit:
- Frequency of and Risk Factors for Stent Thrombosis After Drug-Eluting Stent Implantation During Long-Term Follow-UpThe American Journal of Cardiology, 2006
- Comparison of the effectiveness of sirolimus‐ and paclitaxel‐eluting stents for small coronary artery lesionsCatheterization and Cardiovascular Interventions, 2006
- Comparison of Sirolimus Versus Paclitaxel Eluting Stents for Treatment of Coronary In-Stent RestenosisThe American Journal of Cardiology, 2006
- Predictors of Restenosis After Placement of Drug-Eluting Stents in One or More Coronary ArteriesThe American Journal of Cardiology, 2006
- Comparison of sirolimus‐eluting stent, paclitaxel‐eluting stent, and bare metal stent in the treatment of long coronary lesionsCatheterization and Cardiovascular Interventions, 2006
- Late Loss in Lumen Diameter and Binary Restenosis for Drug-Eluting Stent ComparisonCirculation, 2005
- Surrogates, substudies, and real clinical end points in trials of drug-eluting stentsJournal of the American College of Cardiology, 2005
- Relationship between angiographic late loss and target lesion revascularization after coronary stent implantationJournal of the American College of Cardiology, 2005
- Very long sirolimus-eluting stent implantation for de novo coronary lesionsThe American Journal of Cardiology, 2004
- Impact of lesion complexity on the capacity of a trial to detect differences in stent performance: results from the ISAR-STEREO trialAmerican Heart Journal, 2003