Sleep complaints and their relation with drug treatment in patients suffering from Parkinson's disease
- 6 April 2006
- journal article
- Published by Wiley in Movement Disorders
- Vol. 21 (7), 983-988
- https://doi.org/10.1002/mds.20874
Abstract
The aim of this research was to quantify sleep problems in patients suffering from Parkinson's disease by means of the new Parkinson's Disease Sleep Scale (PDSS) and to correlate such problems with the possible influence of current drug treatment. A total of 70 patients (36 men and 34 women) with a diagnosis of Parkinson's disease were enrolled. Their mean age was 69.7 ± 8.2 years, and duration of disease was 7.4 ± 4.8 years. All patients completed the PDSS and the Unified Parkinson's Disease Rating Scale (UPDRS Parts I–IV). Drug consumption and doses were registered. The mean score on the PDSS scale was 109.23 ± 19.75 and on the UPDRS III scale was 25.24 ± 11.35. The lowest scores were obtained in Item 3 (sleep fragmentation): 5.53 (2.46); and in Item 8 (nocturia): 5.75 (2.91). There was a weak correlation between the PDSS and UPDRS III (cc = −0.355, P = 0.003), PDSS and UPDRS I (cc = −0.272, P = 0.02), and PDSS and UPDRS IV (cc = −0.416, P < 0.001). Motor conditions, mental state, and drug complications influence sleep quality. Although this effect was significant, it was not of a great magnitude. Dopaminergic drugs did not increase daytime sleepiness. As a whole, sleep quality in patients who took dopaminergic agonists did not differ from that of patients who took levodopa in monotherapy. © 2006 Movement Disorder SocietyThis publication has 24 references indexed in Scilit:
- Hallucinations and sleep disorders in PDNeurology, 2005
- Improvement in quality of life in patients with advanced Parkinson's disease following bilateral deep‐brain stimulation in subthalamic nucleusEuropean Journal of Neurology, 2004
- Parkinson's disease sleep scale: Validation study of a Spanish versionMovement Disorders, 2004
- Effects of pergolide on nocturia in Parkinson's disease: three female cases selected from over 400 patientsParkinsonism & Related Disorders, 2004
- Improvement of sleep quality in patients with advanced Parkinson's disease treated with deep brain stimulation of the subthalamic nucleusMovement Disorders, 2003
- Health-Related Quality of Life and sleep disorders in Parkinson?s diseaseNeurological Sciences, 2003
- The Parkinson's disease sleep scale: a new instrument for assessing sleep and nocturnal disability in Parkinson's diseaseJournal of Neurology, Neurosurgery & Psychiatry, 2002
- Sleep disorders in Parkinson's diseaseMovement Disorders, 2002
- Excessive daytime sleepiness in de novo and treated Parkinson's diseaseMovement Disorders, 2002
- Parkinsonʼs disease and sleepCurrent Opinion in Neurology, 2000