MiRNA‐26b regulates the expression of cyclooxygenase‐2 in desferrioxamine‐treated CNE cells
- 25 January 2010
- journal article
- Published by Wiley in FEBS Letters
- Vol. 584 (5), 961-967
- https://doi.org/10.1016/j.febslet.2010.01.036
Abstract
Here we report that miR-26b is involved in COX-2 overexpression in desferrioxamine (DFOM)-treated carcinoma of nasopharyngeal epithelial (CNE) cells. The level of miR-26b in DFOM-treated CNE cells is inversely proportional to the expression level of the COX-2 protein. Overexpression of miR-26b in DFOM-treated CNE cells inhibits cell proliferation. A luciferase reporter gene experiment suggests that the 3' untranslated region of COX-2 carries a binding site for miR-26b. Overexpression of miR-26b marginally reduces the levels of COX-2 protein in DFOM-treated CNE cells. Moreover, knockdown of COX-2 expression had a similar effect to overexpression of miR-26b. Taken together, these results suggest that miR-26b regulates COX-2 expression in DFOM-treated cells.Keywords
Funding Information
- 863 project, China (2006AA6Z402)
- National Natural Sciences Foundation of China (30770592, 60608019)
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