Diverse novel functions of neutrophils in immunity, inflammation, and beyond
Top Cited Papers
Open Access
- 25 June 2013
- journal article
- review article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 210 (7), 1283-1299
- https://doi.org/10.1084/jem.20122220
Abstract
Neutrophils have long been considered simple suicide killers at the bottom of the hierarchy of the immune response. That view began to change 10–20 yr ago, when the sophisticated mechanisms behind how neutrophils locate and eliminate pathogens and regulate immunity and inflammation were discovered. The last few years witnessed a new wave of discoveries about additional novel and unexpected functions of these cells. Neutrophils have been proposed to participate in protection against intracellular pathogens such as viruses and mycobacteria. They have been shown to intimately shape the adaptive immune response at various levels, including marginal zone B cells, plasmacytoid dendritic cells and T cell populations, and even to control NK cell homeostasis. Neutrophils have been shown to mediate an alternative pathway of systemic anaphylaxis and to participate in allergic skin reactions. Finally, neutrophils were found to be involved in physiological and pathological processes beyond the immune system, such as diabetes, atherosclerosis, and thrombus formation. Many of those functions appear to be related to their unique ability to release neutrophil extracellular traps even in the absence of pathogens. This review summarizes those novel findings on versatile functions of neutrophils and how they change our view of neutrophil biology in health and disease.Keywords
This publication has 140 references indexed in Scilit:
- Neutrophil cell surface receptors and their intracellular signal transduction pathwaysInternational Immunopharmacology, 2013
- Neutrophils Exert Protection in the Early Tuberculous Granuloma by Oxidative Killing of Mycobacteria Phagocytosed from Infected MacrophagesCell Host & Microbe, 2012
- Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic LungCancer Cell, 2011
- Neutrophil clearance: when the party is over, clean-up beginsTrends in Immunology, 2011
- Peculiarities of cell death mechanisms in neutrophilsCell Death & Differentiation, 2011
- Alarmins link neutrophils and dendritic cellsTrends in Immunology, 2009
- Coactivation of Syk Kinase and MyD88 Adaptor Protein Pathways by Bacteria Promotes Regulatory Properties of NeutrophilsImmunity, 2009
- Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TANCancer Cell, 2009
- Anaphylaxis: Lessons from mouse modelsJournal of Allergy and Clinical Immunology, 2007
- Blood Dendritic Cells Interact with Splenic Marginal Zone B Cells to Initiate T-Independent Immune ResponsesImmunity, 2002