Common genetic vulnerability for nicotine and alcohol dependence in men.

Abstract
THE RELATIONSHIP between smoking and alcoholism has long interested clinicians and researchers. Smoking is nearly universal in treatment-seeking alcoholic samples1 and has been reported to be as high as 85% in alcoholics identified in a general medical clinic.2 The average number of cigarettes consumed is also significantly higher among alcoholics compared with nonalcoholic smokers,1 with rates of heavy smoking (eg, >25 cigarettes per day) among adult alcoholics as high as 90%.3,4