Sudden cardiac death in 14- to 35-year olds in Ireland from 2005 to 2007: a retrospective registry
Open Access
- 28 July 2011
- journal article
- research article
- Published by Oxford University Press (OUP) in EP Europace
- Vol. 13 (10), 1411-1418
- https://doi.org/10.1093/europace/eur161
Abstract
IntroductionSudden cardiac death (SCD) in young people is a rare but devastating event for families and communities. Ireland has previously had no measure of the incidence of SCD in young people. We report the incidence and causes of SCD in persons <35 years of age.Methods and resultsWe undertook a retrospective study of SCD between 2005 and 2007 in persons aged 15–35 years in the Republic of Ireland. We identified potential cases of out of hospital SCD through the Central Statistics Office (CSO) death certificate records. Autopsy, toxicology, and inquest reports were then obtained and analysed by an expert panel who adjudicated on the cause of death. A total of 342 potential SCD cases were identified through the CSO. Fifty were younger than 15 years of age, and 86 had either incomplete or unavailable post-mortem reports. Of 206 full reports obtained, 116 were adjudicated as cases of SCD. Cases were predominantly male (75%), with a mean age of 25.8 years (standard deviation 6.3). The incidence of SCD in this age range was 2.85 per 100 000 person-years (4.36 for males and 1.30 for females) and the incidence of sudden arrhythmic death syndrome (SADS) was 0.76 per 100 000 person-years. The commonest causes were SADS, 26.7% (31 of 116), followed by coronary artery disease, 20.7% (24 of 116), hypertrophic cardiomyopathy (HCM), 14.7% (17 of 116), and idiopathic left ventricular hypertrophy not fulfilling criteria for HCM, 10.3% (12 of 116).ConclusionsThe incidence of SCD in the young in Ireland was 4.96 (95% CI 3.06, 6.4) for males and 1.3 (95% CI 0.62, 2.56) for females per 100 000 person-years. Sudden arrhythmic death syndrome was the commonest cause of SCD in the young, and the incidence of SADS was more than five times that in official reports of the Irish CSO.This publication has 21 references indexed in Scilit:
- ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac DeathCirculation, 2006
- Demographic and temporal trends in out of hospital sudden cardiac death in BelfastHeart, 2005
- Current burden of sudden cardiac death: Multiple source surveillance versus retrospective death certificate-based review in a large U.S. communityJournal of the American College of Cardiology, 2004
- Temporal Trends in Coronary Heart Disease Mortality and Sudden Cardiac Death From 1950 to 1999Circulation, 2004
- Changing Incidence of Out-of-Hospital Ventricular Fibrillation, 1980-2000JAMA, 2002
- Sudden cardiac death in 15–35‐year olds in Sweden during 1992–99Journal of Internal Medicine, 2002
- Sudden Cardiac Death in the United States, 1989 to 1998Circulation, 2001
- Sudden Death in the General Population in OkinawaJapanese Circulation Journal, 1999
- Out-of-Hospital Cardiac Arrest in the 1990s: A Population-Based Study in the Maastricht Area on Incidence, Characteristics and SurvivalJournal of the American College of Cardiology, 1997
- Comparison of Sudden and Nonsudden Coronary Deaths in the United StatesCirculation, 1996