Multiple Sclerosis

Abstract

(First of Two Parts)The lesions of multiple sclerosis were probably described as early as 1838,¹ but it was Charcot in 1868² who recognized the characteristic clinical and pathologic features of the disease. Since that time, the disorder has been studied extensively. Numerous distinguished, even renowned physicians and scientists have investigated various aspects of multiple sclerosis. Although much has been learned and many theories have emerged, the cause and pathogenesis of this disease remains unknown. No preventive measures or definitive therapies exist. The purpose of this article is to review the classic clinical and pathologic aspects of the disease and . . .