THE FATE OF INJECTED BENCE JONES PROTEIN

Abstract

Bence Jones protein injected into rabbits was excreted rapidly into the urine. The excreted protein retained the physicochemical and immunochemical properties of the injected protein, but a significant portion of the injected protein was metabolized. After reinjection of radioactive Bence Jones protein into the donor patient, only a little radioactivity was recovered in the urinary protein. Implications of these results are discussed.