New insights into the pathophysiology of the dysnatremias: a quantitative analysis
- 1 August 2004
- journal article
- review article
- Published by American Physiological Society in American Journal of Physiology-Renal Physiology
- Vol. 287 (2), F172-F180
- https://doi.org/10.1152/ajprenal.00106.2004
Abstract
Recent theoretical considerations have played an important role in advancing our understanding of the physiological mechanisms responsible for perturbing the plasma water sodium concentration ([Na+]pw) in health and disease. Central to these considerations is the original empirical relationship between the [Na+]pw and total exchangeable sodium (Nae), total exchangeable potassium (Ke), and total body water (TBW) initially discovered by Edelman and colleagues (Edelman IS, Leibman J, O'Meara MP, and Birkenfeld LW. J Clin Invest 37: 1236–1256, 1958). The non-zero values of the slope and y-intercept in the Edelman equation are a consequence of the effects of the osmotic coefficient of Na+ salts at physiological concentrations and Gibbs-Donnan and osmotic equilibrium. Moreover, in addition to Nae, Ke, and TBW, the physiological components of the y-intercept in this equation play a role in modulating the [Na+]pw and in the generation of the dysnatremias. In this review, the pathophysiological mechanisms underlying the generation and treatment of the dysnatremias are analyzed theoretically and quantitatively. Importantly, the non-zero values of both the slope and y-intercept in the Edelman equation result in several theoretical predictions that can be tested experimentally and have been mathematically incorporated into recently derived equations used to analyze both the generation and the optimal treatment of the dysnatremias. In addition, we review current concepts regarding 1) the role of Gibbs-Donnan and osmotic equilibrium in the determination of the [Na+]pw; 2) the modulating effect of osmotically inactive exchangeable Na+ and K+ on the [Na+]pw; 3) the effect of glucose on the [Na+]pw as reflected by changes in Nae, Ke, and TBW as well as changes in several components of the y-intercept resulting from the hyperglycemia; and 4) the complex role of K+ in modulating the [Na+]pw.Keywords
This publication has 27 references indexed in Scilit:
- Role of potassium in hypokalemia-induced hyponatremia: lessons learned from the Edelman equationClinical and Experimental Nephrology, 2004
- Determinants of plasma water sodium concentration as reflected in the Edelman equation: role of osmotic and Gibbs-Donnan equilibriumAmerican Journal of Physiology-Renal Physiology, 2004
- A simple quantitative approach to analyzing the generation of the dysnatremiasClinical and Experimental Nephrology, 2003
- A new quantitative approach to the treatment of the dysnatremiasClinical and Experimental Nephrology, 2003
- The syndrome of inappropriate secretion of antidiuretic hormoneAmerican Journal Of Medicine, 1967
- THE DISPLACEMENT OF SERUM WATER BY THE LIPIDS OF HYPERLIPEMIC SERUM. A NEW METHOD FOR THE RAPID DETERMINATION OF SERUM WATER 1JCI Insight, 1955
- THE EFFECT OF POTASSIUM CHLORIDE ON HYPONATREMIA 1JCI Insight, 1954
- Metabolic Changes Associated with Mitral ValvuloplastyCell Metabolism, 1954
- ELECTROLYTE COMPOSITION OF BONE AND THE PENETRATION OF RADIOSODIUM AND DEUTERIUM OXIDE INTO DOG AND HUMAN BONE 12JCI Insight, 1954
- A Rapid Titrimetric Method for Determining the Water Content of Human BloodScience, 1953