High-level tetracycline resistance in Neisseria gonorrhoeae is result of acquisition of streptococcal tetM determinant
Open Access
- 1 November 1986
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 30 (5), 664-670
- https://doi.org/10.1128/aac.30.5.664
Abstract
Recently, strains of Neisseria gonorrhoeae have been isolated which are highly resistant to tetracycline (MICs of 16 to 64 micrograms/ml). This resistance was due to the acquisition of the resistance determinant tetM, a transposon-borne determinant initially found in the genus Streptococcus and more recently in Mycoplasma hominis, Ureaplasma urealyticum, and Gardnerella vaginalis. In N. gonorrhoeae, the tetM determinant was located on a 25.2-megadalton plasmid. This plasmid arose from the insertion of tetM into the 24.5-megadalton gonococcal conjugative plasmid. The tetM determinant could be transferred to suitable recipient strains of N. gonorrhoeae by both genetic transformation and conjugation.Keywords
This publication has 24 references indexed in Scilit:
- Chromosomally Mediated Resistance in Neisseria gonorrhoeae in the United States: Results of Surveillance and Reporting, 1983-1984The Journal of Infectious Diseases, 1986
- THE GENETICS OF THE GONOCOCCUSAnnual Review of Microbiology, 1984
- Conjugation of Plasmids of Neisseria gonorrhoeae to other Neisseria Species: Potential Reservoirs for the -Lactamase PlasmidThe Journal of Infectious Diseases, 1984
- Acquisition of new genes by oral Neisseria.Journal of Clinical Pathology, 1982
- Neisseria gonorrhoeae isolated from disseminated and localised infections in pre-penicillin era. Auxotypes and antibacterial drug resistances.Sexually Transmitted Infections, 1982
- Intraspecific and Intergeneric Mobilization of Non-conjugative Resistance Plasmids by a 24-5 Megadalton Conjugative Plasmid of Neisseria gonorrhoeaeMicrobiology, 1981
- The Ecology of Gonococcal PlasmidsJournal of General Microbiology, 1979
- Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase IJournal of Molecular Biology, 1977
- Detection of specific sequences among DNA fragments separated by gel electrophoresisJournal of Molecular Biology, 1975
- A membrane-filter technique for the detection of complementary DNABiochemical and Biophysical Research Communications, 1966