Abnormalities in programmed cell death (apoptosis) machinery play a crucial role in initiation progression and metastasis of prostate cancer. Therefore molecules that initiate pro-apoptotic pathways are excellent therapeutic agents in prostate cancer. However some prostate cancer cells develop resistance to pro-apoptotic agents. In this proposal we are examining the regulatory mechanisms of c-FLIP(L) which is an important modulator of apoptosis in prostate cancer.