Antibiotic resistance in the opportunistic pathogen Stenotrophomonas maltophilia
Open Access
- 30 June 2015
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Microbiology
- Vol. 6, 658
- https://doi.org/10.3389/fmicb.2015.00658
Abstract
Stenotrophomonas maltophilia is an environmental bacterium found in the soil, associated with plants and animals, and in aquatic environments. It is also an opportunistic pathogen now causing an increasing number of nosocomial infections. The treatment of S. maltophilia is quite difficult given its intrinsic resistance to a number of antibiotics, and because it is able to acquire new resistances via horizontal gene transfer and mutations. Certainly, strains resistant to quinolones, cotrimoxale and/or cephalosporins - antibiotics commonly used to treat S. maltophilia infections - have emerged. The increasing number of available S. maltophilia genomes has allowed the identification and annotation of a large number of antimicrobial and heavy metal resistance genes. Most encode inactivating enzymes and efflux pumps, but information on their role in intrinsic and acquired resistance is limited. Non-typical antibiotic resistance mechanisms that also form part of the intrinsic resistome have been identified via mutant library screening. These include non-typical antibiotic resistance genes, such as bacterial metabolism genes, and non-inheritable resistant phenotypes, such as biofilm formation and persistence. Their relationships with resistance are complex and require further study.Keywords
This publication has 66 references indexed in Scilit:
- Stenotrophomonas comparative genomics reveals genes and functions that differentiate beneficial and pathogenic bacteriaBMC Genomics, 2014
- Genetic Determinants Involved in the Susceptibility of Pseudomonas aeruginosa to β-Lactam AntibioticsAntimicrobial Agents and Chemotherapy, 2010
- Molecular cloning and characterization of SmrA, a novel ABC multidrug efflux pump from Stenotrophomonas maltophiliaJournal of Antimicrobial Chemotherapy, 2009
- Overexpression of the multidrug efflux pump SmeDEF impairs Stenotrophomonas maltophilia physiologyJournal of Antimicrobial Chemotherapy, 2004
- Class 1 Integrons Increase Trimethoprim-Sulfamethoxazole MICs against Epidemiologically Unrelated Stenotrophomonas maltophilia IsolatesAntimicrobial Agents and Chemotherapy, 2004
- Differential regulation of L1 and L2 beta-lactamase expression in Stenotrophomonas maltophiliaJournal of Antimicrobial Chemotherapy, 2002
- Expression of Multidrug Efflux Pump SmeDEF by Clinical Isolates of Stenotrophomonas maltophiliaAntimicrobial Agents and Chemotherapy, 2001
- Plasmid Location and Molecular Heterogeneity of the L1 and L2 β-Lactamase Genes of Stenotrophomonas maltophiliaAntimicrobial Agents and Chemotherapy, 2001
- Cloning and Characterization of SmeDEF, a Novel Multidrug Efflux Pump from Stenotrophomonas maltophiliaAntimicrobial Agents and Chemotherapy, 2000
- Stenotrophomonas maltophiliaD457R Contains a Cluster of Genes from Gram-Positive Bacteria Involved in Antibiotic and Heavy Metal ResistanceAntimicrobial Agents and Chemotherapy, 2000