Developmental expression patterns of candidate cofactors for vertebrate six family transcription factors
Open Access
- 18 November 2010
- journal article
- patterns and-phenotypes
- Published by Wiley in Developmental Dynamics
- Vol. 239 (12), 3446-3466
- https://doi.org/10.1002/dvdy.22484
Abstract
Six family transcription factors play important roles in craniofacial development. Their transcriptional activity can be modified by cofactor proteins. Two Six genes and one cofactor gene (Eya1) are involved in the human Branchio‐otic (BO) and Branchio‐otic‐renal (BOR) syndromes. However, mutations in Six and Eya genes only account for approximately half of these patients. To discover potential new causative genes, we searched the Xenopus genome for orthologues of Drosophila cofactor proteins that interact with the fly Six‐related factor, SO. We identified 33 Xenopus genes with high sequence identity to 20 of the 25 fly SO‐interacting proteins. We provide the developmental expression patterns of the Xenopus orthologues for 11 of the fly genes, and demonstrate that all are expressed in developing craniofacial tissues with at least partial overlap with Six1/Six2. We speculate that these genes may function as Six‐interacting partners with important roles in vertebrate craniofacial development and perhaps congenital syndromes. Developmental Dynamics 239:3446–3466, 2010.Keywords
This publication has 135 references indexed in Scilit:
- Six2 activity is required for the formation of the mammalian pyloric sphincterDevelopmental Biology, 2009
- Misexpression ofSix2is associated with heritable frontonasal dysplasia and renal hypoplasia in 3H1BrmiceDevelopmental Dynamics, 2008
- Eya1 and Six1 promote neurogenesis in the cranial placodes in a SoxB1-dependent fashionDevelopmental Biology, 2008
- The ERBB3 receptor in cancer and cancer gene therapyCancer Gene Therapy, 2008
- Gene induction following wounding of wild‐type versus macrophage‐deficient Drosophila embryosEMBO Reports, 2008
- Towards a proteome-scale map of the human protein–protein interaction networkNature, 2005
- Induction and specification of the vertebrate ectodermal placodes: precursors of the cranial sensory organsBiology of the Cell, 2005
- Eya protein phosphatase activity regulates Six1–Dach–Eya transcriptional effects in mammalian organogenesisNature, 2003
- Vertebrate Cranial Placodes I. Embryonic InductionDevelopmental Biology, 2001
- A human homologue of the Drosophila eyes absent gene underlies Branchio-Oto-Renal (BOR) syndrome and identifies a novel gene familyNature Genetics, 1997