Manifestations and mechanisms of stem cell aging
Open Access
- 18 April 2011
- journal article
- review article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 193 (2), 257-266
- https://doi.org/10.1083/jcb.201010131
Abstract
Adult stem cells exist in most mammalian organs and tissues and are indispensable for normal tissue homeostasis and repair. In most tissues, there is an age-related decline in stem cell functionality but not a depletion of stem cells. Such functional changes reflect deleterious effects of age on the genome, epigenome, and proteome, some of which arise cell autonomously and others of which are imposed by an age-related change in the local milieu or systemic environment. Notably, some of the changes, particularly epigenomic and proteomic, are potentially reversible, and both environmental and genetic interventions can result in the rejuvenation of aged stem cells. Such findings have profound implications for the stem cell–based therapy of age-related diseases.Keywords
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