Microbiological evaluation of 4-substituted-imidazolidine derivatives
Open Access
- 1 January 2012
- journal article
- Published by OMICS Publishing Group in Indian Journal of Pharmaceutical Sciences
- Vol. 74 (1), 80-3
- https://doi.org/10.4103/0250-474x.102549
Abstract
In the present studies, two series of 4-substituted-imidazolidines (IIIa-i and IIIj,k) were synthesized by reacting different tetrahydro-di-Schiff bases (IIa-i and IIj,k) with p-diethylaminobenzaldehyde/ dimethylaminobenzaldehyde. The title compounds were evaluated for their antibacterial and antifungal actions against some selected microbes. The results of microbiological evaluation revealed that two compounds, 4-(1,3-bis(benzo[d][1,3]dioxol-5-ylmethyl)-4-methylimidazolidin-2-yl)-N,N-diethyl aniline (IIIj), 4-(1,3-bis(benzo[d][1,3]dioxol-5-ylmethyl)-4-methylimidazolidin-2-yl)-N,N-dimethyl aniline (IIIk) were good in their antibacterial as well as antifungal actions. Minimum inhibitory concentration values (MIC) of the compounds are reportedKeywords
This publication has 7 references indexed in Scilit:
- Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X7 antagonistsBioorganic & Medicinal Chemistry Letters, 2010
- Biological and immunological activity of new imidazolidines against adult worms of Schistosoma mansoniZeitschrift für Parasitenkunde, 2010
- Synthesis and biological screening of di- and trisubstituted imidazoles.2009
- Synthesis of 4,5-Diaryl-1H-pyrazole-3-ol Derivatives as Potential COX-2 InhibitorsThe Journal of Organic Chemistry, 2004
- Synthesis of novel tetrahydroimidazole derivatives and studies for their biological properties.European Journal of Medicinal Chemistry, 2001
- Bacteria on the rampageNature, 1996
- New Directions in Antibacterial ResearchJournal of Medicinal Chemistry, 1996