Use of Raman spectroscopy as a tool for in situ monitoring of microwave-promoted reactions
- 20 December 2007
- journal article
- Published by Springer Science and Business Media LLC in Nature Protocols
- Vol. 3 (1), 1-7
- https://doi.org/10.1038/nprot.2007.453
Abstract
The progress of microwave-promoted reactions can be monitored by interfacing a Raman spectrometer with a scientific microwave unit. The apparatus is assembled from commercially available components. It is used in this protocol to follow the base-catalyzed reaction of salicylaldehyde with ethylacetoacetate to yield 3-acetylcoumarin. It is possible to watch the reaction spectroscopically in real time, determine when it reaches completion and thus use it as a tool for rapid reaction optimization.Keywords
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