Microvascular alterations in adult conscious spontaneously hypertensive rats.
- 1 April 1990
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Hypertension
- Vol. 15 (4), 415-419
- https://doi.org/10.1161/01.hyp.15.4.415
Abstract
The dorsal skin flap technique was used to study skeletal muscle microcirculation in conscious 10-12-week-old spontaneously hypertensive rats and normotensive Wistar-Kyoto control rats. Videorecordings were made for off-line analysis of consecutive segments of the vascular bed. Resting diameters were significantly smaller in spontaneously hypertensive rats than in Wistar-Kyoto rats at the first-order (-28%) and second-order arteriolar (-21%) levels. Precapillary third-order and fourth-order arterioles of spontaneously hypertensive rats had normal diameters, whereas postcapillary small venule diameters were slightly larger in spontaneously hypertensive rats. Thirty percent and 41% of the spontaneously hypertensive rat and Wistar-Kyoto rat third-order arteriolar vessels and 63 and 45% of the fourth-order arteriolar vessels exhibited vasomotion. Vasomotion amplitude, but not frequency, was significantly higher in spontaneously hypertensive rats than in Wistar-Kyoto rats. It is concluded that, in the established phase of spontaneous hypertension in the rat, a decreased diameter of large arterioles is the major mechanism underlying the increased vascular resistance in cutaneous skeletal muscle.Keywords
This publication has 14 references indexed in Scilit:
- Power dissipation as a measure of peripheral resistance in vascular networks.Hypertension, 1986
- Localization of vascular resistance changes during hypertension.Hypertension, 1986
- Long-term micro- and macrocirculatory measurements in conscious ratsMicrovascular Research, 1985
- Microvascular pressure, flow, and resistance in spontaneously hypertensive rats.Hypertension, 1984
- Microvascular adaptation in the cerebral cortex of adult spontaneously hypertensive rats.Hypertension, 1984
- Intestinal microvascular adaptation during maturation of spontaneously hypertensive rats.Hypertension, 1983
- The influence of the sympathetic nervous system on individual vessels of the microcirculation of skeletal muscle of the ratThe Journal of Physiology, 1982
- Physiological aspects of primary hypertension.Physiological Reviews, 1982
- Comparison of microvascular pressures in normal and spontaneously hypertensive ratsMicrovascular Research, 1976
- Sympathetic nerve activity: role in regulation of blood pressure in the spontaenously hypertensive rat.Circulation Research, 1976