Role of the Nlrp3 Inflammasome in Microbial Infection
Open Access
- 1 January 2011
- journal article
- Published by Frontiers Media SA in Frontiers in Microbiology
- Vol. 2, 12
- https://doi.org/10.3389/fmicb.2011.00012
Abstract
The intracellular Nod-like receptor Nlrp3 has emerged as the most versatile innate immune receptor because of its broad specificity in mediating immune response to a wide range of microbial or danger signals. Nlrp3 mediates assembly of the inflammasome complex in the presence of microbial components leading to the activation of caspase-1 and the processing and release of the pro-inflammatory cytokines IL-1β and IL-18. In this review, we give an update on the recent literature examining the role of Nlrp3 inflammasome in response to fungal, bacterial, and viral infections.Keywords
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