Effects of a Brown Beans Evening Meal on Metabolic Risk Markers and Appetite Regulating Hormones at a Subsequent Standardized Breakfast: A Randomized Cross-Over Study
Open Access
- 5 April 2013
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 8 (4), e59985
- https://doi.org/10.1371/journal.pone.0059985
Abstract
Background Dietary prevention strategies are increasingly recognized as essential to combat the current epidemic of obesity and related metabolic disorders. The purpose of the present study was to evaluate the potential prebiotic effects of indigestible carbohydrates in Swedish brown beans ( Phaseolus vulgaris var. nanus) in relation to cardiometabolic risk markers and appetite regulating hormones. Methods Brown beans, or white wheat bread (WWB, reference product) were provided as evening meals to 16 healthy young adults in a randomised crossover design. Glucose, insulin, appetite regulatory hormones, GLP-1, GLP-2, appetite sensations, and markers of inflammation were measured at a following standardised breakfast, that is at 11 to 14 h post the evening meals. Additionally, colonic fermentation activity was estimated from measurement of plasma short chain fatty acids (SCFA, including also branched chain fatty acids) and breath hydrogen (H 2 ) excretion. Results An evening meal of brown beans, in comparison with WWB, lowered blood glucose (−15%, p<0.01)- and insulin (−16%, p<0.05) responses, increased satiety hormones (PYY 51%, p<0.001), suppressed hunger hormones (ghrelin −14%, p <0.05), and hunger sensations (−15%, p = 0.05), increased GLP-2 concentrations (8.4%, p <0.05) and suppressed inflammatory markers (IL-6 −35%, and IL-18 −8.3%, p <0.05) at a subsequent standardised breakfast. Breath H 2 (141%, p <0.01), propionate (16%, p <0.05), and isobutyrate (18%, P<0.001) were significantly increased after brown beans compared to after WWB, indicating a higher colonic fermentative activity after brown beans. Conclusions An evening meal with brown beans beneficially affected important measures of cardiometabolic risk and appetite regulatory hormones, within a time frame of 11–14 h, in comparison to a WWB evening meal. Concentrations of plasma SCFA and H 2 were increased, indicating involvement of colonic fermentation. Indigestible colonic substrates from brown beans may provide a preventive tool in relation to obesity and the metabolic syndrome. Trial Registration ClinicalTrials.gov NCT01706042Keywords
This publication has 40 references indexed in Scilit:
- Glucagon-Like Peptide-2 Directly Regulates Hypothalamic Neurons Expressing Neuropeptides Linked to Appetite Control in Vivo and in VitroEndocrinology, 2012
- A diet based on multiple functional concepts improves cardiometabolic risk parameters in healthy subjectsNutrition & Metabolism, 2012
- Food Intake and Satiety Following a Serving of Pulses in Young Men: Effect of Processing, Recipe, and Pulse VarietyJournal of the American College of Nutrition, 2009
- Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty acids and plant sterols in hyperlipidemic individualsAtherosclerosis, 2008
- The potential influence of fruit polyphenols on colonic microflora and human gut healthInternational Journal of Food Microbiology, 2008
- Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditureGastroenterology, 2004
- Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring StudyThe American Journal of Clinical Nutrition, 2002
- Glycemic index: overview of implications in health and disease,,,The American Journal of Clinical Nutrition, 2002
- SCFA increase intestinal Na absorption by induction of NHE3 in rat colon and human intestinal C2/bbe cellsAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2001
- Rapid enzymic assay of insoluble and soluble dietary fiberJournal of Agricultural and Food Chemistry, 1983