Designs for life: protocell models in the laboratory
Top Cited Papers
- 27 September 2011
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Chemical Society Reviews
- Vol. 41 (1), 79-85
- https://doi.org/10.1039/c1cs15211d
Abstract
Compartmentalization of primitive biochemical reactions within membrane-bound water micro-droplets is considered an essential step in the origin of life. In the absence of complex biochemical machinery, the hypothetical precursors to the first biological cells (protocells) would be dependent on the self-organization of their components and physicochemical conditions of the environment to attain a basic level of autonomy and evolutionary viability. Many researchers consider the self-organization of lipid and fatty acid molecules into bilayer vesicles as a simple form of membrane-based compartmentalization that can be developed for the experimental design and construction of plausible protocell models. In this tutorial review, we highlight some of the recent advances and issues concerning the construction of simple cell-like systems in the laboratory. Overcoming many of the current scientific challenges should lead to new types of chemical bio-reactors and artificial cell-like entities, and bring new insights concerning the possible pathways responsible for the origin of life.Keywords
This publication has 32 references indexed in Scilit:
- From Self-Assembled Vesicles to ProtocellsCold Spring Harbor Perspectives in Biology, 2010
- The Origins of Cellular LifeCold Spring Harbor Perspectives in Biology, 2010
- Life as a Nanoscale PhenomenonAngewandte Chemie-International Edition, 2008
- The Emergence of LifePublished by Cambridge University Press (CUP) ,2006
- Synthesizing lifeNature, 2001
- A unifying concept: the history of cell theoryNature, 1999
- Lipid vesicles as possible intermediates in the origin of lifeCurrent Opinion in Colloid & Interface Science, 1999
- The Minimal Gene Complement of Mycoplasma genitaliumScience, 1995
- Origin of life: The RNA worldNature, 1986
- Theory of self-assembly of lipid bilayers and vesiclesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1977