Development and Validation of a Predictive Bone Fracture Risk Model for Astronauts
- 26 August 2009
- journal article
- Published by Springer Science and Business Media LLC in Annals of Biomedical Engineering
- Vol. 37 (11), 2337-2359
- https://doi.org/10.1007/s10439-009-9779-x
Abstract
There are still many unknowns in the physiological response of human beings to space, but compelling evidence indicates that accelerated bone loss will be a consequence of long-duration spaceflight. Lacking phenomenological data on fracture risk in space, we have developed a predictive tool based on biomechanical and bone loading models at any gravitational level of interest. The tool is a statistical model that forecasts fracture risk, bounds the associated uncertainties, and performs sensitivity analysis. In this paper, we focused on events that represent severe consequences for an exploration mission, specifically that of spinal fracture resulting from a routine task (lifting a heavy object up to 60 kg), or a spinal, femoral or wrist fracture due to an accidental fall or an intentional jump from 1 to 2 m. We validated the biomechanical and bone fracture models against terrestrial studies of ground reaction forces, skeletal loading, fracture risk, and fracture incidence. Finally, we predicted fracture risk associated with reference missions to the moon and Mars that represented crew activities on the surface. Fracture was much more likely on Mars due to compromised bone integrity. No statistically significant gender-dependent differences emerged. Wrist fracture was the most likely type of fracture, followed by spinal and hip fracture.Keywords
This publication has 99 references indexed in Scilit:
- Adequacy of laboratory simulation of in-line skater fallsThe Journal of Hand Surgery, 2005
- A dynamic investigation of the burst fracture process using a combined experimental and finite element approachEuropean Spine Journal, 2004
- Les polytraumatismes sont plus graves après chute d’une grande hauteur qu’après accident de la voie publiqueAnnales de Chirurgie, 2003
- Hormone replacement therapy improves distal radius bone structure by endocortical mineral depositionCanadian Journal of Physiology and Pharmacology, 2003
- The relationship between vertebral body deformity and disc degeneration in lumbar spine of the senileEuropean Spine Journal, 1998
- The effect of impact direction on the structural capacity of the proximal femur during fallsJournal of Bone and Mineral Research, 1996
- Finite element stress analysis of simulated metastatic lesions in the lumbar vertebral bodyJournal of Biomedical Engineering, 1992
- Vertical trauma: Injuries to patients who fall and land on their feetAnnals of Emergency Medicine, 1989
- In-Vivo Elastic and Damping Response of the Human Leg to Impact ForcesJournal of Biomechanical Engineering, 1982
- An Experimentally Validated Dynamic Model of the SpineJournal of Applied Mechanics, 1974