Ectopic Pheochromocytoma: Does the Rule of Tens Apply?
- 9 March 2007
- journal article
- research article
- Published by Wiley in World Journal of Surgery
- Vol. 31 (4), 849-854
- https://doi.org/10.1007/s00268-006-0608-1
Abstract
Introduction The rule of “tens” is often stated to reflect the distribution and histology of pheochromocytomas, with 10% being bilateral, 10%; ectopic in origin, and 10%; malignant. The objective of this study was to review the ectopic pheochromocytomas in a tertiary endocrine center and to establish whether the rule of tens holds true. Methods Retrospective data were collected on all adrenalectomies and ectopic pheochromocytoma resections performed between 1993 and 2005 at our institution. Results In total, 77 patients had pheochromocytomas: 75%; (58/77) adrenal and 25%; (19/77) ectopic. Of the adrenal pheochromocytomas, 10%; (6/58) were bilateral. The anatomic locations of the ectopic pheochromocytomas were as follows: 26%; (5/19) adjacent to the adrenals, 53%; (10/19) in the organ of Zuckerkandl, 11%; (2/19) in the bladder, 5%; (1/19) in the mediastinum, and 5%;(1/19) in the neck. Conclusions Our series demonstrates an incidence of 10%; for bilateral pheochromocytoma, which is similar to that in the published reports. However, 25%; of the pheochromocytomas were ectopic. Zuckerkandl pheochromocytomas were the most common among the ectopic lesions. Rarely, these tumors present outside the abdominal cavityThis publication has 30 references indexed in Scilit:
- Overnight excretion of urinary catecholamines and metabolites in the detection of pheochromocytomaJournal of Clinical Endocrinology & Metabolism, 1996
- Diaphragmatic pheochromocytoma.American Journal of Roentgenology, 1995
- Pheochromocytomas, Multiple Endocrine Neoplasia Type 2, and von Hippel-Lindau DiseaseThe New England Journal of Medicine, 1993
- Primary vesical pheochromocytomaUrology, 1983
- Extra-adrenal paragangliomas of the retroperitoneumThe American Journal of Surgical Pathology, 1980
- Catecholamine-secreting paraganglioma. The problem of classificationArchives of Internal Medicine, 1975
- Pheochromocytoma in children: Report of 9 cases and review of the first 100 published cases with follow-up studiesThe Journal of Pediatrics, 1963
- Catecholamines in the Localization of PheochromocytomaCirculation, 1960
- Present Status of Diagnosis and Treatment of PheochromocytomaCirculation, 1957
- INCREASED URINARY EXCRETION OF NORADRENALINE AND ADRENALINE IN CASES OF PHEOCHROMOCYTOMAAnnals of Surgery, 1951