Effect of interaction between 65Zn, mercury and selenium in rats (retention, metallothionein, endogenous copper)
- 1 June 1983
- journal article
- research article
- Published by Springer Science and Business Media LLC in Archives of Toxicology
- Vol. 53 (2), 165-175
- https://doi.org/10.1007/bf00302724
Abstract
Interaction of zinc with mercuric chloride and sodium selenite was studied in the rat at the organ and subcellular levels (liver and kidneys). Zinc chloride was administered subcutaneously at dose of 5 mg Zn/kg, mercury chloride into the tail vein at a dose of 0.5 mg Hg/kg (both metals every other day during 2 weeks) and sodium selenite intragastrically, at doses of 0.1 mg Se/kg, every day. Zinc retention in the rat did not exceed 20% and was unchanged in the presence of mercury. An interaction effect was reflected by an increased whole-body retention of zinc by selenium, mercury, and selenium. In the presence of selenium no peak of metallothionein-like proteins stimulated by zinc or mercury was found in the soluble fraction of the kidneys. The metallothionein level did not differ from that typical for control group animals, too. A significant increase in the level of endogenous copper was found only in the kidneys of rats exposed to zinc in the presence of mercury and selenium.Keywords
This publication has 28 references indexed in Scilit:
- Organ and Subcellular Distribution of Mercury in Rats in the Presence of Cadmium, Zinc, Copper, and Sodium SeleniteClinical Toxicology, 1981
- Effect of mercuric chloride and methylmercury chloride exposure on tissue concentrations of six essential mineralsEnvironmental Research, 1980
- Protection against mercuric chloride by nephrotoxic agents which do not induce thioneinToxicology and Applied Pharmacology, 1980
- Organ and subcellular distribution of mercury in rats as dependent on the time of exposure to sodium seleniteEnvironmental Research, 1979
- Dose dependent formation of zinc-thionein in livers and kidneys of rats and mice by zinc injectionBiochemical Pharmacology, 1979
- Properties of the cadmium and selenium complex formed in rat plasma in vivo and in vitroChemico-Biological Interactions, 1978
- Interactions between selenium compounds and those of mercury or cadmium.Environmental Health Perspectives, 1978
- The influence of selenium on the level of mercury and metallothionein in rat kidneys in prolonged exposure to different mercury compoundsBulletin of Environmental Contamination and Toxicology, 1978
- Interactions of cadmium and selenium in rat plasma in vivo and in vitroBiochimica et Biophysica Acta (BBA) - General Subjects, 1976
- A method for sequential quantitative separation and determination of protein, RNA, DNA, lipid, and glycogen from a single rat liver homogenate or from a subcellular fractionAnalytical Biochemistry, 1967