Expression of transmembrane carbonic anhydrases IX and XII in ovarian tumours
- 27 November 2006
- journal article
- Published by Wiley in Histopathology
- Vol. 49 (6), 594-602
- https://doi.org/10.1111/j.1365-2559.2006.02523.x
Abstract
Aims Carbonic anhydrase (CA) isozymes IX and XII have been suggested to play a role in oncogenic processes. The aim of the present study was to investigate CA IX and XII expression in patients with ovarian tumours. Methods and results A series of ovarian tumours was immunostained for CA IX and XII and the results were correlated with histopathological and clinical parameters. Most cases of borderline mucinous cystadenomas, mucinous cystadenocarcinomas and serous cystadenocarcinomas were moderately or strongly positive for CA IX. In malignant tumours, the staining was most prominent in hypoxic regions. Expression of CA XII was detected in all tumour categories, although the mean staining intensity was weaker than for CA IX in all groups except for clear cell carcinomas. Conclusions The wide expression of CA IX and XII in ovarian tumours suggests that these isozymes could represent potential targets in ovarian cancer therapy. The expression pattern of CA IX suggests that it could also serve as a useful histopathological marker protein for hypoxia in malignant ovarian tumours.Keywords
This publication has 38 references indexed in Scilit:
- Characterization of CA XV, a new GPI-anchored form of carbonic anhydraseBiochemical Journal, 2005
- Hypoxia activates the capacity of tumor‐associated carbonic anhydrase IX to acidify extracellular pHFEBS Letters, 2004
- Specific monoclonal antibody-based immunotherapy by targeting the RCC-associated antigen carbonic anhydrase-IXG250/MNDer Urologe, 2004
- A phase II trial of chimeric monoclonal antibody G250 for advanced renal cell carcinoma patientsBritish Journal of Cancer, 2004
- Carbonic anhydrase isozymes IX and XII in gastric tumorsWorld Journal of Gastroenterology, 2003
- Expression of Hypoxia-Inducible Cell-Surface Transmembrane Carbonic Anhydrases in Human CancerThe American Journal of Pathology, 2001
- Human tumour-associated cell adhesion protein MN/CA IX: identification of M75 epitope and of the region mediating cell adhesionBritish Journal of Cancer, 2000
- Identification of carbonic anhydrase XII as the membrane isozyme expressed in the normal human endometrial epitheliumMolecular Human Reproduction, 2000
- HumanMN/CA9Gene, a Novel Member of the Carbonic Anhydrase Family: Structure and Exon to Protein Domain RelationshipsGenomics, 1996
- A novel quasi-viral agent, MaTu, is a two-component systemVirology, 1992