Temporal lobe interictal epileptic discharges affect cerebral activity in “default mode” brain regions
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Open Access
- 28 November 2006
- journal article
- research article
- Published by Wiley in Human Brain Mapping
- Vol. 28 (10), 1023-1032
- https://doi.org/10.1002/hbm.20323
Abstract
A cerebral network comprising precuneus, medial frontal, and temporoparietal cortices is less active both during goal-directed behavior and states of reduced consciousness than during conscious rest. We tested the hypothesis that the interictal epileptic discharges affect activity in these brain regions in patients with temporal lobe epilepsy who have complex partial seizures. At the group level, using electroencephalography-correlated functional magnetic resonance imaging in 19 consecutive patients with focal epilepsy, we found common decreases of resting state activity in 9 patients with temporal lobe epilepsy (TLE) but not in 10 patients with extra-TLE. We infer that the functional consequences of TLE interictal epileptic discharges are different from those in extra-TLE and affect ongoing brain function. Activity increases were detected in the ipsilateral hippocampus in patients with TLE, and in subthalamic, bilateral superior temporal and medial frontal brain regions in patients with extra-TLE, possibly indicating effects of different interictal epileptic discharge propagation. Hum Brain Mapp 2006.Keywords
This publication has 45 references indexed in Scilit:
- Cortical and thalamic fMRI responses in partial epilepsy with focal and bilateral synchronous spikesClinical Neurophysiology, 2006
- Default brain functionality in blind peopleProceedings of the National Academy of Sciences of the United States of America, 2004
- Positive and Negative Network Correlations in Temporal Lobe EpilepsyCerebral Cortex, 2004
- EEG‐fMRI of focal epileptic spikes: Analysis with multiple haemodynamic functions and comparison with gadolinium‐enhanced MR angiogramsHuman Brain Mapping, 2004
- Cognitive impairment during epileptiform discharges: is it ever justifiable to treat the EEG?The Lancet Neurology, 2003
- fMRI “deactivation” of the posterior cingulate during generalized spike and waveNeuroImage, 2003
- Frontal Lobe Seizure Propagation: Scalp and Subdural EEG StudiesEpilepsia, 2001
- A Method for Removing Imaging Artifact from Continuous EEG Recorded during Functional MRINeuroImage, 2000
- Identification of EEG Events in the MR Scanner: The Problem of Pulse Artifact and a Method for Its SubtractionNeuroImage, 1998
- Origin and propagation of interictal discharges in the acute electrocorticogram. Implications for pathophysiology and surgical treatment of temporal lobe epilepsyBrain, 1997