Real‐time monitoring of the setting reaction of brushite‐forming cement using isothermal differential scanning calorimetry
- 5 May 2006
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research Part B: Applied Biomaterials
- Vol. 79B (2), 360-364
- https://doi.org/10.1002/jbm.b.30550
Abstract
The setting behavior of a brushite‐forming cement (β‐tricalcium phosphate/mono calcium monophosphate) was investigated using an indentation technique (the Gillmore needles method) and isothermal differential scanning calorimetry (DSC). The two objectives of the study were to investigate whether DSC could be used to real‐time monitor a fast‐setting calcium phosphate cement (CPC) and to determine if it is possible to correlate DSC results directly with conventional setting‐time measurements. Best‐fit linear correlation analysis revealed that both the initial and final setting time (Ti and Tf) measured by indentation were strongly correlated to the maximum heat flow measured with DSC. It seems therefore possible to predict the setting times, usually achieved with user dependent indentation methods, of this specific fast setting CPC on the basis of objective DSC measurements. The drawbacks of DSC, however, are its overall complexity and expense and the fact that only exothermal reactions can be investigated in comparison to the Gillmore needles method, furthermore, it is not possible to monitor the complete reaction as the first 2 or 3 min are lost due to sample preparation and apparatus set up. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006Keywords
This publication has 26 references indexed in Scilit:
- Correlating crystallinity and reactivity in an α-tricalcium phosphateBiomaterials, 2005
- Stearate Salts as Brushite Bone Cement Setting RetardantsKey Engineering Materials, 2005
- Influence of powder/liquid mixing ratio on the performance of a restorative glass-ionomer dental cementBiomaterials, 2003
- Mechanical activation and cement formation of β-tricalcium phosphateBiomaterials, 2003
- Kinetic Model for α–Tricalcium Phosphate HydrolysisJournal of the American Ceramic Society, 2002
- Ultrasonic characterization of the curing process of hydroxyapatite-modified bone cementJournal of Biomedical Materials Research, 2001
- Effects of Sulfate, Pyrophosphate, and Citrate Ions on the Physicochemical Properties of Cements Made of β‐Tricalcium Phosphate‐Phosphoric Acid‐Water MixturesJournal of the American Ceramic Society, 1996
- Effects of Na2HPO4 and NaH2PO4 on hydroxyapatite formationJournal of Biomedical Materials Research, 1993
- Development of Self-Setting Calcium Phosphate CementsJournal of the Ceramic Society of Japan, 1991
- Calcium phosphate cements: study of the β-tricalcium phosphate — monocalcium phosphate systemBiomaterials, 1989