Estimation of Ferrokinetic Parameters by a Mathematical Model in Patients with Primary Acquired Sideroblastic Anaemia

Abstract

Ferrokinetic parameters were estimated in 8 patients with primary acquired sideroblastic anemia (PASA) by means of a mathematical model of iron kinetics. Plasma 59Fe clearance and red cell utilization curves were used to identify the model parameters. The close agreement between experimental and theoretical data proved that the model can describe iron kinetics in sideroblastic anemia. Ineffective erythropoiesis was the major factor in the production of the anemia. Various degrees and patterns of peripheral hemolysis were observed. The storage iron was always markedly increased, and a large non-erythroid iron turnover was calculated in the most severely affected patients. The results are compared with present knowledge of erythropoiesis in PASA.