Mycoplasma genitalium Macrolide and Fluoroquinolone Resistance Detection and Clinical Implications in a Selected Cohort in New Zealand
Open Access
- 1 November 2017
- journal article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 55 (11), 3242-3248
- https://doi.org/10.1128/jcm.01087-17
Abstract
Mycoplasma genitalium has been associated with infections of the genitourinary tract, and prevalence is secondary to Chlamydia trachomatis . The clinical observation of increasing treatment failure indicating antibiotic resistance, especially in cases of recurrent urethritis, has been confirmed by molecular testing. Mutations in the 23S rRNA gene can cause macrolide resistance, and topoisomerase/gyrase mutations can cause fluoroquinolone resistance. In this study, 115 M. genitalium DNA-positive samples were analyzed. Eighty-nine (77.4%) samples had a 23S rRNA mutation present, and 26 (22.6%) were wild type (no resistance mutation). Fluoroquinolone mutation screening was performed on 86 (74.8%) of the 115 samples, of which 20 (23.3%) samples had a mutation or mutations associated with increased resistance. This study shows the increasing antibiotic resistance in New Zealand and the need for appropriate guidelines to treat at-risk patients.Keywords
Funding Information
- Canterbury Medical Research Foundation (15/05)
This publication has 23 references indexed in Scilit:
- Increasing Macrolide and Fluoroquinolone Resistance in Mycoplasma genitaliumEmerging Infectious Diseases, 2017
- Emergence of Mycoplasma genitalium strains showing mutations associated with macrolide and fluoroquinolone resistance in the region Dresden, GermanyDiagnostic Microbiology and Infectious Disease, 2016
- Background review for the 2016 European guideline on Mycoplasma genitalium infectionsJournal of the European Academy of Dermatology and Venereology, 2016
- Remarkable increase in fluoroquinolone-resistant Mycoplasma genitalium in JapanJournal of Antimicrobial Chemotherapy, 2014
- Failure of moxifloxacin treatment in Mycoplasma genitalium infections due to macrolide and fluoroquinolone resistanceInternational Journal of STD & AIDS, 2013
- Fluoroquinolone and Macrolide Resistance-Associated Mutations in Mycoplasma genitaliumJournal of Clinical Microbiology, 2013
- Emergence of clinical strains of Mycoplasma genitalium harbouring alterations in ParC associated with fluoroquinolone resistanceInternational Journal of Antimicrobial Agents, 2010
- Persistence of Mycoplasma genitalium Following Azithromycin TherapyPLOS ONE, 2008
- Mycoplasma genitalium Among Young Adults in the United States: An Emerging Sexually Transmitted InfectionAmerican Journal of Public Health, 2007
- Use of TaqMan 5′ Nuclease Real-Time PCR for Quantitative Detection of Mycoplasma genitalium DNA in Males with and without Urethritis Who Were Attendees at a Sexually Transmitted Disease ClinicJournal of Clinical Microbiology, 2004