Potential antidiabetic and antioxidant activities of Morus indica and Asystasia gangetica in alloxan-induced diabetes mellitus
Open Access
- 1 February 2010
- journal article
- Published by Taylor & Francis Ltd in Journal of Experimental Pharmacology
- Vol. 2, 29-36
- https://doi.org/10.2147/JEP.S8947
Abstract
Potential antidiabetic and antioxidant activities of Morus indica and Asystasia gangetica in alloxaninduced diabetes mellitus R Pradeep Kumar,1 D Sujatha,2 TS Mohamed Saleem,1 C Madhusudhana Chetty,1 D Ranganayakulu21Department of Pharmacology, Annamacharya College of Pharmacy, Rajampet, India; 2Department of Pharmacology, Sri Padmavathi School of Pharmacy, Tirupathi, India Herbal drugs are frequently considered to be less toxic and also free from side effects, than synthetic ones. Hence, the present study was designed to investigate one such combination of herbal drugs, Asystasia gangetica and Morus indica for their antidiabetic and antioxidant potential against alloxan-induced diabetes in albino rats. The effect of both individual and a combination of Asystasia gangetica and Morus indica on blood glucose and liver glycogen were studied in the diabetic rats. The study also assessed for the effect of selected plant extracts for their effect on Superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and Lipid peroxidation (LPO) in the homogenates of the pancreas. The results of the present study attests significant antidiabetic and antioxidant potential for the selected plants individually and also in combination as a prominent decrease in blood glucose and liver glycogen was observed in the rats treated with the extracts of the selected plants. Similarly, the levels of the protective antioxidant enzymes like SOD, CAT and GSH were increased along with decrease in the LPO levels. The present study provides a scientific evidence for antidiabetic and antioxidant potential of Asystasia gangetica and Morus indica. Further studies to isolate bioactive compounds will pave the way to identify potential lead compounds for developing safe and efficacious antidiabetic agents.Keywords: hypoglycemic effect, herbal drugs, lipid peroxidation, hyperglycemia, diabetic animalsKeywords
This publication has 27 references indexed in Scilit:
- Hypoglycemic and Antihyperglycemic Effect of Gmelina asiatica LINN. in Normal and in Alloxan Induced Diabetic RatsBiological & Pharmaceutical Bulletin, 2005
- Catalase and Superoxide Dismutase: Distribution, Properties, and Physiological Role in Cells of Strict AnaerobesBiochemistry (Moscow), 2004
- Antidiabetic activity of aqueous leaf extract of Annona squamosa in streptozotocin–nicotinamide type 2 diabetic ratsJournal of Ethnopharmacology, 2004
- Evaluation of the anti-asthmatic property of Asystasia gangetica leaf extractsJournal of Ethnopharmacology, 2003
- Antioxidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin-diabetic ratsClinica Chimica Acta; International Journal of Clinical Chemistry, 2003
- Lipid peroxidation and antioxidant status in experimental diabetesClinica Chimica Acta; International Journal of Clinical Chemistry, 1999
- The role of manganese superoxide dismutase in health and diseaseJournal of Inherited Metabolic Disease, 1998
- Effect of oral methionine on blood lipid peroxidation and antioxidants in alloxaninduced diabetic ratsThe Journal of Nutritional Biochemistry, 1990
- Traditional Plant Medicines as Treatments for DiabetesDiabetes Care, 1989
- Hypoglycemic activity of Artemisia herba albaJournal of Ethnopharmacology, 1988