A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression Analysis
Open Access
- 13 June 2010
- journal article
- review article
- Published by Hindawi Limited in Journal of Biomedicine and Biotechnology
- Vol. 2010, 1-7
- https://doi.org/10.1155/2010/361841
Abstract
For the past 50 years, quality control and safety tests have been used to evaluate vaccine safety. However, conventional animal safety tests need to be improved in several aspects. For example, the number of test animals used needs to be reduced and the test period shortened. It is, therefore, necessary to develop a new vaccine evaluation system. In this review, we show that gene expression patterns are well correlated to biological responses in vaccinated rats. Our findings and methods using experimental biology and genome science provide an important means of assessment for vaccine toxicity.Keywords
Funding Information
- Ministry of Health, Labour and Welfare
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