Abstract
It has been almost three years since the Journal 1 published the results of AIDS Clinical Trials Group (ACTG) Study 076, the first randomized, controlled trial in which an intervention was proved to reduce the incidence of human immunodeficiency virus (HIV) infection. The antiretroviral drug zidovudine, administered orally to HIV-positive pregnant women in the United States and France, administered intravenously during labor, and subsequently administered to the newborn infants, reduced the incidence of HIV infection by two thirds.2 The regimen can save the life of one of every seven infants born to HIV-infected women.Because of these findings, the study was . . .